{"id":28774,"date":"2025-04-11T10:59:42","date_gmt":"2025-04-11T01:59:42","guid":{"rendered":"https:\/\/www.marketresearch.jp\/reports\/?p=28774"},"modified":"2026-09-20T15:12:05","modified_gmt":"2026-09-20T06:12:05","slug":"histone-deacetylase-inhibitors-market-gmi","status":"publish","type":"post","link":"https:\/\/www.marketresearch.jp\/reports\/histone-deacetylase-inhibitors-market-gmi\/","title":{"rendered":"\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u306e\u4e16\u754c\u5e02\u5834\uff082025-3034\uff09\uff1a\u7a2e\u985e\u5225(\u30d2\u30c9\u30ed\u30ad\u30b5\u30e0\u9178\u8a98\u5c0e\u4f53\u3001\u74b0\u72b6\u30da\u30d7\u30c1\u30c9\u3001\u30d9\u30f3\u30ba\u30a2\u30df\u30c9)\u3001\u6cbb\u7642\u6cd5\u5225"},"content":{"rendered":"

\"\"<\/p>\n

\u7b2c1\u7ae0 \u65b9\u6cd5\u8ad6\u3068\u7bc4\u56f2
\n1.1 \u5e02\u5834\u7bc4\u56f2\u3068\u5b9a\u7fa9
\n1.2 \u8abf\u67fb\u30c7\u30b6\u30a4\u30f3
\n1.2.1 \u8abf\u67fb\u30a2\u30d7\u30ed\u30fc\u30c1
\n1.2.2 \u30c7\u30fc\u30bf\u53ce\u96c6\u65b9\u6cd5
\n1.3 \u30d9\u30fc\u30b9\u3068\u306a\u308b\u63a8\u5b9a\u3068\u8a08\u7b97
\n1.3.1 \u57fa\u6e96\u5e74\u306e\u7b97\u51fa
\n1.3.2 \u5e02\u5834\u63a8\u8a08\u306e\u4e3b\u8981\u30c8\u30ec\u30f3\u30c9
\n1.4 \u4e88\u6e2c\u30e2\u30c7\u30eb
\n1.5 \u4e00\u6b21\u8abf\u67fb\u3068\u691c\u8a3c
\n1.5.1 \u4e00\u6b21\u60c5\u5831\u6e90
\n1.5.2 \u30c7\u30fc\u30bf\u30de\u30a4\u30cb\u30f3\u30b0\u30bd\u30fc\u30b9
\n\u7b2c2\u7ae0 \u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30b5\u30de\u30ea\u30fc
\n2.1 \u696d\u754c360\u00b0\u306e\u6982\u8981
\n\u7b2c3\u7ae0 \u696d\u754c\u30a4\u30f3\u30b5\u30a4\u30c8
\n3.1 \u696d\u754c\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u5206\u6790
\n3.2 \u696d\u754c\u306e\u5f71\u97ff\u529b
\n3.2.1 \u6210\u9577\u30c9\u30e9\u30a4\u30d0\u30fc
\n3.2.1.1 \u764c\u7f79\u60a3\u7387\u306e\u4e0a\u6607
\n3.2.1.2 \u304c\u3093\u9818\u57df\u4ee5\u5916\u3078\u306e\u5fdc\u7528\u62e1\u5927
\n3.2.1.3 \u7814\u7a76\u958b\u767a\u6295\u8cc7\u3068\u81e8\u5e8a\u8a66\u9a13\u306e\u5897\u52a0
\n3.2.1.4 \u85ac\u4e8b\u627f\u8a8d\u3068\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u306e\u6307\u5b9a
\n3.2.2 \u696d\u754c\u306e\u843d\u3068\u3057\u7a74\u3068\u8ab2\u984c
\n3.2.2.1 \u9ad8\u3044\u6cbb\u7642\u8cbb
\n3.2.2.2 \u6bd2\u6027\u3068\u526f\u4f5c\u7528
\n3.3 \u6210\u9577\u53ef\u80fd\u6027\u5206\u6790
\n3.4 \u898f\u5236\u30e9\u30f3\u30c9\u30b9\u30b1\u30fc\u30d7
\n3.5 \u30ae\u30e3\u30c3\u30d7\u5206\u6790
\n3.6 \u7279\u8a31\u5206\u6790
\n3.7 \u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u5206\u6790
\n3.8 \u30dd\u30fc\u30bf\u30fc\u5206\u6790
\n3.9 PESTEL\u5206\u6790
\n\u7b2c4\u7ae0 \u7af6\u4e89\u74b0\u5883\uff082024\u5e74
\n4.1 \u306f\u3058\u3081\u306b
\n4.2 \u4f01\u696d\u30b7\u30a7\u30a2\u5206\u6790
\n4.3 \u4f01\u696d\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5206\u6790
\n4.4 \u4e3b\u8981\u5e02\u5834\u30d7\u30ec\u30fc\u30e4\u30fc\u306e\u7af6\u5408\u5206\u6790
\n4.5 \u7af6\u5408\u306e\u30dd\u30b8\u30b7\u30e7\u30cb\u30f3\u30b0\u30de\u30c8\u30ea\u30c3\u30af\u30b9
\n4.6 \u6226\u7565\u30c0\u30c3\u30b7\u30e5\u30dc\u30fc\u30c9
\n\u7b2c5\u7ae0 2021\u301c2034\u5e74\u85ac\u52b9\u5206\u985e\u5225\u5e02\u5834\u63a8\u5b9a\u30fb\u4e88\u6e2c\uff08\u5358\u4f4d\uff1a\u767e\u4e07\u30c9\u30eb\uff09
\n5.1 \u4e3b\u8981\u30c8\u30ec\u30f3\u30c9
\n5.2 \u30d2\u30c9\u30ed\u30ad\u30b5\u30e0\u9178\u8a98\u5c0e\u4f53
\n5.3 \u74b0\u72b6\u30da\u30d7\u30c1\u30c9
\n5.4 \u30d9\u30f3\u30b6\u30df\u30c9
\n\u7b2c6\u7ae0 \u7528\u9014\u5225\u5e02\u5834\u4e88\u6e2c\uff1a2021\u301c2034\u5e74 ($ Mn)
\n6.1 \u4e3b\u8981\u30c8\u30ec\u30f3\u30c9
\n6.2 \u304c\u3093\u9818\u57df
\n6.3 \u795e\u7d4c
\n6.4 \u305d\u306e\u4ed6\u306e\u7528\u9014
\n\u7b2c7\u7ae0 2021\u301c2034\u5e74\u6d41\u901a\u30c1\u30e3\u30cd\u30eb\u5225\u5e02\u5834\u4e88\u6e2c\u30fb\u4e88\u6e2c \uff08$ Mn\uff09
\n7.1 \u4e3b\u8981\u52d5\u5411
\n7.2 \u75c5\u9662\u85ac\u5c40
\n7.3 \u5c0f\u58f2\u85ac\u5c40
\n7.4 E\u30b3\u30de\u30fc\u30b9
\n\u7b2c8\u7ae0 2021\u301c2034\u5e74\u5730\u57df\u5225\u5e02\u5834\u4e88\u6e2c\u30fb\u4e88\u6e2c \uff08$ Mn\uff09
\n8.1 \u4e3b\u8981\u52d5\u5411
\n8.2 \u5317\u7c73
\n8.2.1 \u30a2\u30e1\u30ea\u30ab
\n8.2.2 \u30ab\u30ca\u30c0
\n8.3 \u30e8\u30fc\u30ed\u30c3\u30d1
\n8.3.1 \u30c9\u30a4\u30c4
\n8.3.2 \u30a4\u30ae\u30ea\u30b9
\n8.3.3 \u30d5\u30e9\u30f3\u30b9
\n8.3.4 \u30b9\u30da\u30a4\u30f3
\n8.3.5 \u30a4\u30bf\u30ea\u30a2
\n8.3.6 \u30aa\u30e9\u30f3\u30c0
\n8.4 \u30a2\u30b8\u30a2\u592a\u5e73\u6d0b
\n8.4.1 \u4e2d\u56fd
\n8.4.2 \u65e5\u672c
\n8.4.3 \u30a4\u30f3\u30c9
\n8.4.4 \u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2
\n8.4.5 \u97d3\u56fd
\n8.5 \u30e9\u30c6\u30f3\u30a2\u30e1\u30ea\u30ab
\n8.5.1 \u30d6\u30e9\u30b8\u30eb
\n8.5.2 \u30e1\u30ad\u30b7\u30b3
\n8.5.3 \u30a2\u30eb\u30bc\u30f3\u30c1\u30f3
\n8.6 \u4e2d\u6771\u30fb\u30a2\u30d5\u30ea\u30ab
\n8.6.1 \u5357\u30a2\u30d5\u30ea\u30ab
\n8.6.2 \u30b5\u30a6\u30b8\u30a2\u30e9\u30d3\u30a2
\n8.6.3 \u30a2\u30e9\u30d6\u9996\u9577\u56fd\u9023\u90a6
\n\u7b2c9\u7ae0 \u4f01\u696d\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb
\n9.1 Bristol-Myers Squibb Company
\n9.2 Chipscreen Bioscience
\n9.3 ITF Therapeutics
\n9.4 Merck & Co.
\n9.5 Novartis
\n9.6 Spectrum Pharmaceuticals
\n9.7 Taizhou EOC Pharma<\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

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\u3055\u3089\u306b\u3001\u3088\u308a\u5e83\u7bc4\u306a\u81e8\u5e8a\u7528\u9014\u3001\u4f75\u7528\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3001\u3088\u308a\u9ad8\u3044\u6709\u52b9\u6027\u3092\u6709\u3059\u308b\u65b0\u305f\u306aHDAC\u963b\u5bb3\u5264\u3092\u5275\u51fa\u3059\u308b\u305f\u3081\u306e\u88fd\u85ac\u30e1\u30fc\u30ab\u30fc\u306b\u3088\u308b\u7814\u7a76\u958b\u767a\u6295\u8cc7\u306e\u62e1\u5927\u304c\u3001\u5e02\u5834\u306e\u6210\u9577\u3092\u652f\u3048\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u30012024\u5e743\u6708\u3001\u30a2\u30e1\u30ea\u30ab\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306f\u30016\u6b73\u4ee5\u4e0a\u306e\u30c7\u30e5\u30b7\u30a7\u30f3\u30cc\u578b\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\uff08DMD\uff09\u60a3\u8005\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3001ITF Therapeutics\u793e\u306e\u7d4c\u53e3HDAC\u963b\u5bb3\u5264\u3067\u3042\u308b\u30c7\u30e5\u30d3\u30b6\u30c3\u30c8\uff08\u30b8\u30d3\u30ce\u30b9\u30bf\u30c3\u30c8\uff09\u3092\u627f\u8a8d\u3057\u307e\u3057\u305f\u3002\u88fd\u85ac\u4f01\u696d\u306b\u3088\u308b\u53d6\u308a\u7d44\u307f\u3068\u898f\u5236\u5f53\u5c40\u306e\u627f\u8a8d\u30b5\u30dd\u30fc\u30c8\u304c\u3001\u5e02\u5834\u6210\u9577\u306e\u539f\u52d5\u529b\u306b\u306a\u308a\u305d\u3046\u3067\u3059\u3002<\/p>\n

\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u306e\u5e02\u5834\u52d5\u5411
\nHDAC\u963b\u5bb3\u5264\u5e02\u5834\u306f\u3001\u5f93\u6765\u306e\u816b\u760d\u5b66\u3078\u306e\u5fdc\u7528\u304b\u3089\u3001\u795e\u7d4c\u5b66\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3001\u708e\u75c7\u6027\u75be\u60a3\u306a\u3069\u306e\u4ed6\u306e\u81e8\u5e8a\u9818\u57df\u3078\u306e\u30b7\u30d5\u30c8\u304c\u3001\u60a3\u8005\u306eQOL\u3001\u751f\u5b58\u7387\u3001\u6cbb\u7642\u52b9\u679c\u306e\u6539\u5584\u3092\u3082\u305f\u3089\u3059\u65b0\u305f\u306a\u963b\u5bb3\u5264\u306e\u7814\u7a76\u958b\u767a\uff08R&D\uff09\u3092\u4fc3\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001AI\u6280\u8853\u306e\u5c0e\u5165\u306b\u3088\u308a\u3001HDAC\u963b\u5bb3\u5264\u5e02\u5834\u306b\u304a\u3051\u308b\u5275\u85ac\u30fb\u958b\u767a\u30d7\u30ed\u30bb\u30b9\u306e\u6709\u52b9\u6027\u304c\u3055\u3089\u306b\u5411\u4e0a\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u30012024\u5e746\u6708\u3001Italfarmaco\u793e\u306fIktos\u793e\u3068\u3001\u5148\u9032\u7684\u306aHDAC\u963b\u5bb3\u5264\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306bAI\u306e\u52a9\u3051\u3092\u501f\u308a\u3066\u975e\u304c\u3093\u6cbb\u7642\u85ac\u306e\u8a2d\u8a08\u3092\u52a0\u901f\u3059\u308b\u5951\u7d04\u3092\u7de0\u7d50\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u6b27\u5dde\u533b\u85ac\u54c1\u5e81\uff08EMA\uff09\u3001\u7c73\u56fd\u533b\u85ac\u54c1\u5e81\uff08NMPA\uff09\u3001\u30a2\u30e1\u30ea\u30abFDA\u306a\u3069\u306e\u898f\u5236\u6a5f\u95a2\u306f\u3001HDAC\u963b\u5bb3\u5264\u5e02\u5834\u3067\u6d3b\u52d5\u3059\u308b\u88fd\u85ac\u4f1a\u793e\u306b\u8cb4\u91cd\u306a\u652f\u63f4\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u3084T\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306e\u3088\u3046\u306a\u653b\u6483\u7684\u3067\u73cd\u3057\u3044\u764c\u306b\u5bfe\u3059\u308b\u65b0\u85ac\u306e\u9700\u8981\u304c\u975e\u5e38\u306b\u9ad8\u3044\u305f\u3081\u3001\u898f\u5236\u6a5f\u95a2\u306f\u8cc7\u91d1\u63f4\u52a9\u3001\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u306e\u6307\u5b9a\u3001\u65e9\u671f\u627f\u8a8d\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u306e\u5e02\u5834\u5206\u6790
\n\u30d2\u30c9\u30ed\u30ad\u30b5\u30e0\u9178\u8a98\u5c0e\u4f53\u306f\u9ad8\u3044\u4e9c\u925b\u7d50\u5408\u80fd\u3092\u6709\u3057\u3066\u304a\u308a\u3001HDAC\u963b\u5bb3\u5264\u306e\u4e2d\u3067\u6700\u3082\u5f37\u529b\u306a\u30af\u30e9\u30b9\u306e\u4e00\u3064\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u30d2\u30c9\u30ed\u30ad\u30b5\u30e0\u9178\u306f\u304c\u3093\u6cbb\u7642\u306b\u304a\u3044\u3066\u5b9f\u8cea\u7684\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u30012021\u5e748\u6708\u306b\u7c73\u56fd\u5316\u5b66\u4f1a\u304c\u767a\u8868\u3057\u305f\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u30013\u7a2e\u985e\u306e\u30d2\u30c9\u30ed\u30ad\u30b5\u30e0\u9178\u30d9\u30fc\u30b9\u306eHDAC\u963b\u5bb3\u5264\u304cT\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3068\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u3068T\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306e\u75c7\u4f8b\u6570\u306e\u5897\u52a0\u306f\u3001\u4e88\u6e2c\u671f\u9593\u4e2d\u306b\u30d2\u30c9\u30ed\u30ad\u30b5\u30e0\u9178\u30d9\u30fc\u30b9\u306eHDAC\u963b\u5bb3\u5264\u306e\u9700\u8981\u3092\u4fc3\u9032\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7c73\u56fd\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\uff08NIH\uff09\u306b\u3088\u308b\u3068\u30012022\u5e74\u306b\u306f\u3001\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u306b\u3088\u308b\u65b0\u305f\u306a\u75c7\u4f8b\u304c\u4e16\u754c\u306718\u4e078,000\u4ef6\u3001\u6b7b\u4ea1\u304c12\u4e071,000\u4ef6\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u30d2\u30c9\u30ed\u30ad\u30b5\u30e0\u9178\u8a98\u5c0e\u4f53\u306e\u5316\u5b66\u7642\u6cd5\u8010\u6027\u6291\u5236\u52b9\u679c\u3084\u816b\u760d\u6210\u9577\u6291\u5236\u52b9\u679c\u3082\u3001\u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u30d2\u30c9\u30ed\u30ad\u30b5\u30e0\u9178\u8a98\u5c0e\u4f53\u306e\u4f7f\u7528\u5897\u52a0\u306e\u4e00\u52a9\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u3053\u306e\u30bb\u30b0\u30e1\u30f3\u30c8\u306e\u6210\u9577\u3092\u4fc3\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

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\u52a0\u3048\u3066\u3001HDAC\u963b\u5bb3\u5264\u3001\u5316\u5b66\u7642\u6cd5\u3001\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u5264\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u3068\u306e\u4f75\u7528\u7642\u6cd5\u306e\u4f7f\u7528\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u3001\u540c\u5206\u91ce\u306e\u6210\u9577\u3092\u5f8c\u62bc\u3057\u3057\u3066\u3044\u307e\u3059\u3002\u4f75\u7528\u7642\u6cd5\u306f\u3001\u304c\u3093\u60a3\u8005\u306e\u751f\u5b58\u7387\u3068\u6cbb\u7642\u52b9\u679c\u3092\u5927\u5e45\u306b\u6539\u5584\u3057\u307e\u3059\u3002<\/p>\n

HDAC\u963b\u5bb3\u5264\u5e02\u5834\u306f\u3001\u6d41\u901a\u30c1\u30e3\u30cd\u30eb\u5225\u306b\u75c5\u9662\u85ac\u5c40\u3001\u5c0f\u58f2\u85ac\u5c40\u3001\u96fb\u5b50\u5546\u53d6\u5f15\u306b\u533a\u5206\u3055\u308c\u307e\u3059\u30022024\u5e74\u306e\u58f2\u4e0a\u9ad8\u306f\u75c5\u9662\u85ac\u5c40\u304c8\u51043,070\u4e07\u7c73\u30c9\u30eb\u3067\u6700\u5927\u3002<\/p>\n

\u30d9\u30ea\u30ce\u30b9\u30bf\u30c3\u30c8\u3001\u30d1\u30ce\u30d3\u30ce\u30b9\u30bf\u30c3\u30c8\u3001\u30dc\u30ea\u30ce\u30b9\u30bf\u30c3\u30c8\u306e\u3088\u3046\u306a\u627f\u8a8d\u3055\u308c\u305fHDAC\u963b\u5bb3\u5264\u306e\u4e00\u90e8\u306f\u3001\u7d99\u7d9a\u7684\u306a\u60a3\u8005\u76e3\u8996\u3068\u53b3\u683c\u306a\u6295\u4e0e\u91cf\u898f\u5236\u3092\u5fc5\u8981\u3068\u3059\u308b\u305f\u3081\u3001\u75c5\u9662\u8abf\u5264\u65bd\u8a2d\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u91cd\u5927\u306a\u6bd2\u6027\u30ea\u30b9\u30af\u3084\u526f\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u304c\u3042\u308bHDAC\u963b\u5bb3\u5264\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u898f\u5236\u5f53\u5c40\u306b\u3088\u308b\u9662\u5185\u6295\u4e0e\u8981\u4ef6\u304c\u3001\u75c5\u9662\u85ac\u5c40\u30bb\u30b0\u30e1\u30f3\u30c8\u306e\u53ce\u76ca\u6210\u9577\u3092\u4fc3\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u75c5\u9662\u306e\u3088\u3046\u306a\u6025\u6027\u671f\u533b\u7642\u65bd\u8a2d\u3067\u306f\u3001\u816b\u760d\u79d1\u75c5\u68df\u3084\u8f38\u6db2\u30bb\u30f3\u30bf\u30fc\u304c\u6574\u5099\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u304c\u3093\u6cbb\u7642\u306e\u5927\u534a\u304c\u6291\u5236\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u75c5\u9662\u85ac\u5c40\u30bb\u30b0\u30e1\u30f3\u30c8\u306e\u53ce\u76ca\u6210\u9577\u3092\u3055\u3089\u306b\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n

\u7c73\u56fdFDA\u306a\u3069\u306e\u898f\u5236\u6a5f\u95a2\u306f\u3001\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u306e\u627f\u8a8d\u3001\u512a\u5148\u5be9\u67fb\u3001\u30d5\u30a1\u30b9\u30c8\u30fb\u30c8\u30e9\u30c3\u30af\u6307\u5b9a\u306a\u3069\u3001\u65b0\u305f\u306a\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u6cbb\u7642\u306e\u7814\u7a76\u3068\u4e0a\u5e02\u306b\u6ce8\u529b\u3057\u3066\u304a\u308a\u3001\u5e02\u5834\u306e\u6210\u9577\u3092\u5f8c\u62bc\u3057\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001Pharmacyclics\u793e\u306b\u3088\u308b\u8907\u6570\u306e\u304c\u3093\u7a2e\u3092\u5bfe\u8c61\u3068\u3057\u305f\u65b0\u898f\u7d4c\u53e3HDAC\u963b\u5bb3\u5264abexinostat\u306f\u3001\u6570\u591a\u304f\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u85ac\u5264\u306f2019\u5e749\u6708\u306bFDA\u304b\u3089\u8fc5\u901f\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u30a2\u30e1\u30ea\u30ab\u306b\u304a\u3051\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u6709\u75c5\u7387\u306e\u5897\u52a0\u306f\u3001\u305d\u306e\u6f5c\u5728\u7684\u306a\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u306b\u3088\u308a\u3001HDAC\u963b\u5bb3\u5264\u3078\u306e\u95a2\u5fc3\u3092\u6025\u4e0a\u6607\u3055\u305b\u3066\u3044\u307e\u3059\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u5354\u4f1a\u306e2024\u5e74\u30d5\u30a1\u30af\u30c8\u30b7\u30fc\u30c8\u306b\u3088\u308b\u3068\u3001\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u7d04700\u4e07\u4eba\u306e\u60a3\u8005\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u7f79\u60a3\u3057\u3066\u304a\u308a\u30012050\u5e74\u307e\u3067\u306b\u7f79\u60a3\u60a3\u8005\u306f1300\u4e07\u4eba\u306b\u5897\u52a0\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba \u30b9\u30af\u30a4\u30d6\u793e\u3001\u30e1\u30eb\u30af\u793e\u3001\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9\u793e\u306a\u3069\u3001\u65b0\u3057\u3044\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u306e\u958b\u767a\u30fb\u8ca9\u58f2\u306b\u53c2\u753b\u3057\u3066\u3044\u308b\u591a\u6570\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3084\u88fd\u85ac\u4f01\u696d\u306e\u5b58\u5728\u3082\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u5e02\u5834\u6210\u9577\u3092\u5f8c\u62bc\u3057\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30e8\u30fc\u30ed\u30c3\u30d1 \u82f1\u56fd\u306e\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u5e02\u5834\u306f\u30012025\u5e74\u304b\u30892034\u5e74\u306b\u304b\u3051\u3066\u5927\u304d\u306a\u6210\u9577\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u82f1\u56fd\u3067\u306f\u3001\u9ad8\u9f62\u5316\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3001\u4e0d\u5065\u5eb7\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306a\u3069\u306e\u8981\u56e0\u306b\u3088\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u764c\u306e\u767a\u751f\u7387\u304c\u9ad8\u307e\u3063\u3066\u304a\u308a\u3001HDAC\u963b\u5bb3\u5264\u306a\u3069\u306e\u65b0\u898f\u6cbb\u7642\u85ac\u306b\u5bfe\u3059\u308b\u9700\u8981\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001Cancer Research UK\u306b\u3088\u308b\u3068\u3001\u82f1\u56fd\u3067\u306f\u6bce\u5e74\u7d0438\u4e075,000\u4eba\u304c\u65b0\u305f\u306b\u304c\u3093\u3068\u8a3a\u65ad\u3055\u308c\u3066\u304a\u308a\u3001\u52b9\u679c\u7684\u306a\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u5fc5\u8981\u6027\u304c\u6d6e\u304d\u5f6b\u308a\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u9769\u65b0\u7684\u306aHDAC\u963b\u5bb3\u5264\u306e\u81e8\u5e8a\u4f7f\u7528\u3068\u627f\u8a8d\u306b\u5bfe\u3059\u308bMHRA\uff08Medicines and Healthcare products Regulatory Agency\uff1a\u533b\u85ac\u54c1\u30fb\u533b\u7642\u88fd\u54c1\u898f\u5236\u5e81\uff09\u306b\u3088\u308b\u898f\u5236\u4e0a\u306e\u652f\u63f4\u304c\u3001\u540c\u5730\u57df\u306e\u5e02\u5834\u6210\u9577\u3092\u4fc3\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30a2\u30b8\u30a2\u592a\u5e73\u6d0b\u5730\u57df \u65e5\u672c\u306e\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u85ac\u5e02\u5834\u306f\u30012025\u5e74\u304b\u30892034\u5e74\u306b\u304b\u3051\u3066\u6709\u5229\u306a\u6210\u9577\u304c\u898b\u8fbc\u307e\u308c\u307e\u3059\u3002<\/p>\n

\u65e5\u672c\u306f\u3001\u9ad8\u9f62\u8005\u4eba\u53e3\u304c\u591a\u304f\u3001\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u30a6\u30a4\u30eb\u30b91\u578b\uff08HTLV-1\uff09\u306e\u611f\u67d3\u7387\u304c\u9ad8\u3044\u305f\u3081\u3001\u30ea\u30f3\u30d1\u816b\u306e\u4e2d\u3067\u3082\u4fb5\u653b\u6027\u306e\u9ad8\u3044\u6210\u4ebaT\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306e\u767a\u751f\u7387\u304c\u9ad8\u3044\u50be\u5411\u306b\u3042\u308a\u307e\u3059\u3002Wiley Online Library\u306b\u3088\u308b\u3068\u3001\u65e5\u672c\u3067\u306f\u6bce\u5e74\u7d044000\u4ef6\u306eHTLV-1\u611f\u67d3\u75c7\u304c\u65b0\u305f\u306b\u767a\u751f\u3057\u3001\u305d\u306e\u5e74\u306eHTLV-1\u611f\u67d3\u8005\u6570\u306f100\u4e07\u4eba\u3092\u8d85\u3048\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u6210\u4ebaT\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306b\u3088\u308a\u6bce\u5e741000\u4eba\u4ee5\u4e0a\u304c\u6b7b\u4ea1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

HDAC\u963b\u5bb3\u5264\u306f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u4fee\u98fe\u3092\u6a19\u7684\u3068\u3057\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u80fd\u529b\u306b\u3088\u308a\u3001T\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306e\u7ba1\u7406\u304a\u3088\u3073\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3059\u3002\u30bf\u30bc\u30e1\u30c8\u30b9\u30bf\u30c3\u30c8\u3084\u30ed\u30df\u30c7\u30d7\u30b7\u30f3\u306a\u3069\u306eHDAC\u963b\u5bb3\u5264\u306f\u65e5\u672c\u3067\u627f\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u75be\u60a3\u306e\u7ba1\u7406\u306b\u6709\u52b9\u3067\u3042\u308b\u305f\u3081\u3001\u3053\u306e\u5730\u57df\u306e\u5e02\u5834\u6210\u9577\u3092\u727d\u5f15\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4e2d\u6771\u30fb\u30a2\u30d5\u30ea\u30ab\uff1a \u30b5\u30a6\u30b8\u30a2\u30e9\u30d3\u30a2\u306e\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u5e02\u5834\u306f\u30012025\u5e74\u304b\u30892034\u5e74\u306b\u304b\u3051\u3066\u5927\u5e45\u304b\u3064\u6709\u671b\u306a\u6210\u9577\u304c\u898b\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30b5\u30a6\u30b8\u30a2\u30e9\u30d3\u30a2\u306f\u3001\u653f\u5e9c\u306e\u3055\u307e\u3056\u307e\u306a\u53d6\u308a\u7d44\u307f\u3084\u6d77\u5916\u304b\u3089\u306e\u6295\u8cc7\u306b\u3088\u308a\u3001\u533b\u7642\u30a4\u30f3\u30d5\u30e9\u304c\u6700\u3082\u6025\u901f\u306b\u767a\u5c55\u3057\u3066\u3044\u308b\u56fd\u306e\u4e00\u3064\u3067\u3059\u3002\u304c\u3093\u306b\u5bfe\u3059\u308b\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u76ee\u7684\u3068\u3057\u305f\u3001\u304c\u3093\u5c02\u9580\u306e\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3084\u81e8\u5e8a\u8a66\u9a13\u306e\u8a2d\u7acb\u304c\u3001\u540c\u5730\u57df\u306e\u5e02\u5834\u6210\u9577\u3092\u5f8c\u62bc\u3057\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u540c\u56fd\u306b\u304a\u3051\u308b\u304c\u3093\u306e\u7f79\u60a3\u7387\u306e\u5897\u52a0\u304c\u3001HDAC\u963b\u5bb3\u5264\u306e\u3088\u3046\u306a\u9769\u65b0\u7684\u306a\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u306e\u9700\u8981\u3092\u4fc3\u9032\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30b5\u30a6\u30b8\u30a2\u30e9\u30d3\u30a2\u4fdd\u5065\u8a55\u8b70\u4f1a\u306b\u3088\u308b\u3068\u3001\u30b5\u30a6\u30b8\u30a2\u30e9\u30d3\u30a2\u3067\u306f2022\u5e74\u306b\u304c\u3093\u306b\u95a2\u9023\u3059\u308b\u65b0\u898f\u75c7\u4f8b\u304c\u7d0428,100\u4ef6\u3001\u6b7b\u4ea1\u4f8b\u304c\u7d0413,400\u4ef6\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

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\u5e02\u5834\u306f\u3001\u898f\u5236\u5f53\u5c40\u306e\u652f\u63f4\u3068\u627f\u8a8d\u30d7\u30ed\u30bb\u30b9\u306e\u5408\u7406\u5316\u306b\u3088\u308a\u3001\u6280\u8853\u9769\u65b0\u3078\u306e\u610f\u6b32\u3092\u9ad8\u3081\u3001\u5e02\u5834\u53c2\u5165\u3092\u4fc3\u9032\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001ITF Therapeutics\u793e\u3084Spectrum Pharmaceuticals\u793e\u306a\u3069\u306e\u65b0\u8208\u4f01\u696d\u306f\u3001\u75be\u60a3\u7ba1\u7406\u306e\u6539\u5584\u3092\u76ee\u7684\u3068\u3057\u305f\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u6ce8\u529b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u6280\u8853\u9769\u65b0\u306f\u3001\u5f15\u304d\u7d9a\u304d\u5e02\u5834\u306e\u62e1\u5927\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n

\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u5e02\u5834\u53c2\u5165\u4f01\u696d
\n\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u696d\u754c\u3067\u4e8b\u696d\u3092\u5c55\u958b\u3059\u308b\u8457\u540d\u306a\u5e02\u5834\u53c2\u5165\u4f01\u696d\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\uff1a<\/p>\n

Bristol-Myers Squibb Company
\nChipscreen Bioscience
\nITF Therapeutics
\nMerck & Co.
\nNovartis
\nSpectrum Pharmaceuticals
\nTaizhou EOC Pharma<\/p>\n

\u30e1\u30eb\u30af\u30fb\u30a2\u30f3\u30c9\u30fb\u30ab\u30f3\u30d1\u30cb\u30fc\uff08Merck&Co. \u540c\u793e\u306f\u3001\u30a2\u30e1\u30ea\u30abFDA\u304b\u3089\u521d\u3081\u3066\u627f\u8a8d\u3055\u308c\u305fHDAC\u963b\u5bb3\u5264\u3067\u3042\u308b\u30dc\u30ea\u30ce\u30b9\u30bf\u30c3\u30c8\uff08\u30be\u30ea\u30f3\u30b6\uff09\u3092\u3001\u76ae\u819aT\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff08CTCL\uff09\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u540c\u793e\u306f\u5e83\u7bc4\u306a\u8ca9\u58f2\u7db2\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u6cbb\u7642\u85ac\u304c\u9060\u9694\u5730\u306b\u3082\u5c4a\u304f\u3053\u3068\u3092\u4fdd\u8a3c\u3057\u3001\u30ea\u30fc\u30c1\u3092\u62e1\u5927\u3057\u3066\u3044\u307e\u3059\u3002
\n\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9\u306f\u3001HDAC\u963b\u5bb3\u5264\u5e02\u5834\u3067\u5f37\u3044\u5b58\u5728\u611f\u3092\u793a\u3059\u30b0\u30ed\u30fc\u30d0\u30eb\u4f01\u696d\u3067\u3059\u3002\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u306e\u6cbb\u7642\u3092\u9069\u5fdc\u75c7\u3068\u3059\u308b\u540c\u793e\u306eHDAC\u963b\u5bb3\u5264\u30d1\u30ce\u30d3\u30ce\u30b9\u30bf\u30c3\u30c8\uff08\u30d5\u30a1\u30ea\u30c0\u30c3\u30af\uff09\u306f\u3001\u5927\u304d\u306a\u5e02\u5834\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u540c\u793e\u306f\u9ad8\u5ea6\u306a\u7814\u7a76\u958b\u767a\u80fd\u529b\u3092\u6d3b\u7528\u3057\u3001HDAC\u963b\u5bb3\u5264\u306e\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u3092\u63a8\u9032\u3002<\/p>\n

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\n2024\u5e744\u6708\u3001\u30c1\u30c3\u30d7\u30b9\u30af\u30ea\u30fc\u30f3\u30fb\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9\u793e\u306f\u3001R-CHOP\uff08\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3001\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3001\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3001\u30d7\u30ec\u30c9\u30cb\u30be\u30f3\uff09\u3068\u306e\u4f75\u7528\u306b\u3088\u308b\u7d4c\u53e3\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\uff08HDAC\uff09\u963b\u5bb3\u5264\u3067\u3042\u308b\u30c1\u30c0\u30df\u30c9\uff08\u30a8\u30d4\u30c0\u30b6\uff09\u304c\u56fd\u5bb6\u533b\u85ac\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u306b\u3088\u308a\u627f\u8a8d\u3055\u308c\u305f\u3068\u767a\u8868\u3002<\/p>\n

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2024\u5e743\u6708\u3001ITF\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u306f\u30016\u6b73\u4ee5\u4e0a\u306e\u30c7\u30e5\u30b7\u30a7\u30f3\u30cc\u578b\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\uff08DMD\uff09\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u30b8\u30d3\u30ce\u30b9\u30bf\u30c3\u30c8\uff08\u30c7\u30e5\u30d3\u30b6\u30c3\u30c8\uff09\u304c\u30a2\u30e1\u30ea\u30abFDA\u3088\u308a\u627f\u8a8d\u3055\u308c\u305f\u3053\u3068\u3092\u767a\u8868\u3002\u3053\u306e\u627f\u8a8d\u306b\u3088\u308a\u3001\u540c\u793e\u306fHDAC\u963b\u5bb3\u5264\u5e02\u5834\u306b\u304a\u3051\u308b\u5730\u4f4d\u3092\u5f37\u5316\u3057\u3001\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa\u3092\u5927\u5e45\u306b\u62e1\u5927\u3057\u307e\u3057\u305f\u3002<\/p>\n

2019\u5e7411\u6708\u3001\u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba \u30b9\u30af\u30a4\u30d6\u30fb\u30ab\u30f3\u30d1\u30cb\u30fc\u306f\u30bb\u30eb\u30b8\u30fc\u30f3\u30fb\u30b3\u30fc\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u8cb7\u53ce\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u8cb7\u53ce\u306b\u3088\u308a\u3001\u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba \u30b9\u30af\u30a4\u30d6\u30fb\u30ab\u30f3\u30d1\u30cb\u30fc\u306f\u30bb\u30eb\u30b8\u30fc\u30f3\u304b\u3089\u30ed\u30df\u30c7\u30d7\u30b7\u30f3HDAC\u963b\u5bb3\u5264\u6cbb\u7642\u85ac\u3092\u53d6\u5f97\u3057\u3001\u5e02\u5834\u3067\u306e\u5b58\u5728\u611f\u3092\u5927\u304d\u304f\u9ad8\u3081\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

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\u5e02\u5834, \u85ac\u5264\u30af\u30e9\u30b9\u5225<\/p>\n

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\n\u74b0\u72b6\u30da\u30d7\u30c1\u30c9
\n\u30d9\u30f3\u30ba\u30a2\u30df\u30c9
\n\u5e02\u5834\uff1a\u7528\u9014\u5225<\/p>\n

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\n\u795e\u7d4c\u5b66
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\n\u5e02\u5834\uff1a\u6d41\u901a\u30c1\u30e3\u30cd\u30eb\u5225<\/p>\n

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